Endocrine Abstracts

Introduction: Ultrasound-guided fine-needle aspiration cytology (US-FNAC), the gold standard method to distinguish benign from malignant thyroid nodules, is the most accurate, cost-effective and minimal invasive preoperative test, aiming to resolve patient management. However, up to 30% of US-FNACs are classified as indeterminate nodules, making difficult to avoid unnecessary surgeries. Molecular tests may contribute to refine the preoperative diagnosis of thyroid nodules....

Introduction: Several studies recommend the use of molecular tests for a complete diagnosis of malignancy in thyroid carcinomas (TC). The study and identification of molecular markers in thyroid will contribute to a personalized and effective treatment of the patients. The development of TC has been associated with the activation of oncogenes that are implicated in the cell signaling pathway, interfering in cancer promotion and outcome. Moreover, the repertoire of microRNAs (m...

Introduction: The diagnostic gold standard for thyroid nodular disease is ultrasound-guided fine-needle aspiration cytology (US-FNAC), being the most accurate, cost-effective and minimal invasive preoperative test to distinguish benign from malignant nodules, aiming to resolve patient management. However, up to 30% of FNACs are classified as indeterminate nodules, turning difficult the decision on patient management to avoid unnecessary surgeries. The development of thyroid ca...